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Paleo Diet Linked to High Levels of Harmful Gut Bacteria

Nellie D. Ashmore by Nellie D. Ashmore
December 4, 2025
in Diet
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People who comply with the Paleo weight-reduction plan often accomplish that for health motives, eschewing many carbs, especially grains, in preferring lean meats and veggies. Now, studies show that this “caveman” fashion of consuming may additionally have hidden dangers for your coronary heart health.

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Paleo Diet Linked to High Levels of Harmful Gut Bacteria 1
The Paleo weight loss program, which draws dietary tips from the diets of our human ancestors, advocates consuming like a hunter and gatherer—eating lots of meat, vegetables, nuts, and some result—at the same time as aside from agriculturally-based totally meals which includes grains, legumes, and dairy, together with delicate sugar and processed oils.

Though no person could argue the nutritional merits of veggies and lean protein, pulling whole grains out of the food plan can also have some dangerous hidden effects concerning the intestine microbiome and how it influences cardiovascular fitness, consistent with a new study posted inside the European Journal of Nutrition.
Researchers from Edith Cowan University in Perth, Western Australia, in comparison the intestine microbiomes and levels of trimethylamine-n-oxide (TMAO)—a key blood biomarker strongly related to heart sickness—of 44 folks who observed the Paleo weight-reduction plan for at least 365 days with a comparable organization of 47 folks that observed the advocated Australian weight-reduction plan that includes entire grains.
They found that those who ate Paleo had tiers of TMAO twice as excessive as their non-Paleo ingesting friends.
The reason? A loss of complete grains in the Paleo food regimen led researcher Angela Genoni, Ph.D., in a press launch.

“We discovered the dearth of complete grains were associated with TMAO degrees, which may provide a link among the reduced risks of cardiovascular ailment we see in populations with excessive intakes of whole grains,” she said within the release.

The researchers also observed higher concentrations of the bacteria that produce TMAO within the Paleo eating regimen follower’s microbiome. Consuming whole grains may downregulate, or suppress, the species of microorganism that produce TMAO in the bowel, Genoni informed Bicycling.
“The Paleo food regimen excludes all grains, and we recognize that entire grains are a wonderful supply of resistant starch and lots of different fermentable fibers which are critical to the health of your gut microbiome,” Genoni stated inside the launch.

In recent years, TMAO has emerged as a critical impartial cardiac chance thing. Two studies by way of Cleveland Clinic posted in New England Journal of Medicine and Nature Medicine in 2013 found that excessive TMAO tiers should expect the danger of a destiny cardiac occasion even in folks who don’t have conventional danger factors that you’d discover in different blood tests—think excessive cholesterol levels or triglycerides.
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The Cleveland Clinic team located that looks at participants with the best tiers of TMAO have been 2.Five times more likely to have a main cardiovascular occasion like a coronary heart assault, stroke, or demise, than those with the lowest levels.

The researchers also found that populations of beneficial bacteria species were decreased inside the Paleo weight-reduction plan fans, which also becomes related to reduced carbohydrate consumption. That “may have effects for other continual sicknesses over a long time,” Genoni stated inside the release
This echoes the findings of a 2016 meta-analysis of forty-five research published inside the British Medical Journal that suggested that complete grain intake turned into related to a reduced danger of coronary coronary heart sickness, cardiovascular ailment, cancer, diabetes, respiration diseases, and dying from all reasons.

It’s also worth noting that a growing body of research, consisting of 2017, has a look at in Nature that analyzed dental plaque from stays courting to the Paleolithic duration. It has shown that our ancestors from that point did include grains tubers, and sugary culmination as dietary staples.
While nobody advocates ingesting processed junk, fueling your rides with wholesome complete grains can be correct in your wattage in addition to your cardiovascular and typical fitness—and may not be “anti Paleo” besides.

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